Analysis of associations of polymorphic variants of sites binding of microRNAs to primary osteoporosis in men and women

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Doklady Bashkirskogo Universiteta. 2018. Volume 3. No. 4. pp. 483-489.

Authors

Yalaev B. I.*
Institute of Biochemistry and Genetics UFRC RAS
71 Prospekt Oktyabrya, 450054 Ufa, Republic of Bashkortostan, Russia
Khusainova R. I.
Institute of Biochemistry and Genetics UFRC RAS
71 Prospekt Oktyabrya, 450054 Ufa, Republic of Bashkortostan, Russia

Abstract

The role of polymorphic loci of the binding site of microRNAs in the mRNA of genes that play a significant role in bone metabolism was studied, and association searching was carry out with the risk of osteoporotic fractures and low level of bone mineral density.

Keywords

  • microRNA
  • site of binding of microRNA
  • osteoporosis
  • bone mineral density
  • epigenetics
  • genotyping
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