Исследование ассоциации полиморфных вариантов генов IL8 и IL10 с риском развития рака желудка

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Доклады Башкирского университета. 2017. Том 2. № 1. С. 41-47.

Авторы

Нургалиева А. Х.*
Башкирский государственный университет
Россия, Республика Башкортостан, 450076 г. Уфа, улица Заки Валиди, 32
Юсупова Л. Ф.
Башкирский государственный университет
Россия, Республика Башкортостан, 450076 г. Уфа, улица Заки Валиди, 32
Хуснутдинова Э. К.
Башкирский государственный университет; Институт биохимии и генетики УНЦ РАН
Россия, Республика Башкортостан, 450076 г. Уфа, улица Заки Валиди, 32; Россия, Республика Башкортостан, 450075 г. Уфа, проспект Октября, 71

Абстракт

Проведено ассоциативное исследование полиморфных вариантов генов цитокинов интерлейкина-8 IL8 ( rs4073 ) и интерлейкина-10 IL10 ( rs1800872 ) у больных раком желудка и здоровых доноров из РБ. Выявлены ассоциации полиморфного варианта rs1800872 гена IL10 с риском развития РЖ в этнических группах русских и татар.

Ключевые слова

  • рак желудка
  • гены цитокинов
  • полиморфный вариант
  • ассоциация

Литература

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Association study of IL8 and IL10 genes polymorphisms in gastric cancer development

Authors

Nurgalieva A. Kh.*
Bashkir State University
32 Zaki Validi Street, 450074 Ufa, Republic of Bashkortostan, Russia
Yusupova L. F.
Bashkir State University
32 Zaki Validi Street, 450074 Ufa, Republic of Bashkortostan, Russia
Khusnutdinova E. K.
Bashkir State University; Institute of Biochemistry and Genetics, Russian Academy of Sciences
32 Zaki Validi Street, 450074 Ufa, Republic of Bashkortostan, Russia; 71 Prospekt Oktyabrya, 450075 Ufa, Republic of Bashkortostan, Russia

Abstract

An associative study of cytokine gene polymorphisms of interleukin-8 IL8 (rs4073) and interleukin-10 IL10 (rs1800872) in gastric cancer patients and healthy donors from the Bashkortostan Republic. There were been found associations of a polymorphic variant rs1800872 of IL10 gene with the risk of gastric cancer in Russians and Tatars.

Keywords

  • gastric cancer
  • cytokine genes
  • polymorphisms
  • association
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