Synthesis and cytotoxicity of 2-(3-pyridine-3-ylmethylene)-oleanolic acid and its morpholinamide
Doklady Bashkirskogo Universiteta. 2019. Volume 4. No. 6. pp. 618-621.
Authors
Petrova A. V.*
Ufa Institute of Chemistry, Ufa Federal Research Centre of the Russian Academy of Science
71 Oktyabrya Avenue, 450054 Ufa, Republic of Bashkortostan, Russia
*E-mail: pnastya08@mail.ru
Kukovinets O. S.
Bashkir State University
32 Zaki Validi Street, 450076 Ufa, Republic of Bashkortostan, Russia
Zileeva Z. R.
Institute of Biochemistry and Genetics, Ufa Federal Research Centre of the Russian Academy of Sciences
71 Oktyabrya Avenue, 450054, Ufa, Republic of Bashkortostan, Russia
Ivanova T. V.
Institute of Biochemistry and Genetics, Ufa Federal Research Centre of the Russian Academy of Sciences
71 Oktyabrya Avenue, 450054, Ufa, Republic of Bashkortostan, Russia
Abstract
By successive reactions (Claisen-Schmidt condensation, amidation via the acid chloride method), new derivatives of oleanolic acid containing fragments of 3-pyridine-3-ylmethylene in position C2 and morpholine in C28 were synthesized, and their cytotoxicity was studied.
Keywords
- oleanolic acid
- synthesis
- cytotoxicity