Synthesis and сytotoxicity of new derivatives of 20-oxo-29-nor-lupanes

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Doklady Bashkirskogo Universiteta. 2019. Volume 4. No. 6. pp. 613-617.

Authors

Galimova Z. I.
Bashkir State University
32 Zaki Validi Street, 450076 Ufa, Republic of Bashkortostan, Russia
Timerbaeva L. Z.
Bashkir State University
32 Zaki Validi Street, 450076 Ufa, Republic of Bashkortostan, Russia
Fedorova A. A.
Bashkir State University
32 Zaki Validi Street, 450076 Ufa, Republic of Bashkortostan, Russia
Zileeva Z. R.
Institute of Biochemistry and Genetics, Ufa Federal Research Centre of the Russian Academy of Sciences
71 Oktyabrya Avenue, 450054, Ufa, Republic of Bashkortostan, Russia
Ivanova T. V.
Institute of Biochemistry and Genetics, Ufa Federal Research Centre of the Russian Academy of Sciences
71 Oktyabrya Avenue, 450054, Ufa, Republic of Bashkortostan, Russia
Khusnutdinova E. F.
Ufa Institute of Chemistry, Ufa Federal Research Centre of the Russian Academy of Science
71 Oktyabrya Avenue, 450054 Ufa, Republic of Bashkortostan, Russia

Abstract

The new platanic acid derivatives modified at the C2, C3 and C30-positions of triterpene core were synthesized for the first time. The study of cytotoxicity against cancer cell lines showed higher potency of C2-mono- and C2,C30-dipiridinylidenoerivatives of methyl platanoate.

Keywords

  • triterpenoids
  • platanic acid
  • anticancer activity
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