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Diagnostic significance of ovarian cancer markers СА 125 and НЕ4

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Doklady Bashkirskogo Universiteta. 2018. Volume 3. No. 4. pp. 403-410.

Authors

Zaripova L. M.*
Bashkir State University; Emergency Hospital
32 Zaki Validi Street, 450074 Ufa, Republic of Bashkortostan, Russia; 18 Naberezhnochelninskiy Prospekt, 423803 Naberezhnye Chelny, Republic of Tatarstan, Russia.
Veselov P. Yu.
Polyclinic N50, Inter-municipal Oncological Center
19 Komsomolskaya Street, 450001 Ufa, Republic of Bashkortostan, Russia
Veselov S. Yu.
Bashkir State University
32 Zaki Validi Street, 450074 Ufa, Republic of Bashkortostan, Russia

Abstract

During the process of study we characterized tumor markers СА 125 and НЕ4 used for diagnostics of ovarian cancer. The use of discriminating level >35 U/ml for СА 125 and >70 pmol/L for НЕ4 (independent of age) enabled 81-89% sensitivity at the early stages of disease. The use of ROMA algorithm implicating concentration of both markers and some other indexes does not allow us to increase the effectiveness of early cancer detection.

Keywords

  • ovarian cancer
  • tumor marker СА 125
  • tumor marker НЕ4
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