Podophyllotoxin-producing plants

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Doklady Bashkirskogo Universiteta. 2018. Volume 3. No. 1. pp. 37-48.

Authors

Saprykina P. D.
Bashkir State University
32 Zaki Validi Street, 450074 Ufa, Republic of Bashkortostan, Russia
Taipova R. M.
Bashkir State University
32 Zaki Validi Street, 450074 Ufa, Republic of Bashkortostan, Russia
Kuluev B. R.*
Bashkir State University; Institute of Biochemistry and Genetics of Ufa Scientific Center of RAS
32 Zaki Validi Street, 450074 Ufa, Republic of Bashkortostan, Russia; 71 Prospect Oktyabrya, 450054 Ufa, Republic of Bashkortostan, Russia

Abstract

This review is devoted to the description of natural sources of lignan with anti-cancer properties - podophyllotoxin (PTOX). Presently known are its natural sources, the main applications in medicine, as well as possible ways to obtain PTOX by biotechnology production. The prospects of using Podophyllum hexandrum hairy roots for the production of PTOX on an industrial scale are noted. As a natural source of podophyllotoxin for the central part of Russia, the use of Anthriscus sylvestris is recommended, in addition, in the southern regions of our country, different types of juniper, especially Juniperus sabina , can be used for this purpose.

Keywords

  • podophyllotoxin
  • PTOX
  • Podophyllum hexandrum
  • Anthriscus sylvestris
  • Juniperus sabina
  • suspension cultures
  • hairy roots
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