Synthesis and cytotoxicity of N-ethyl/methylpiperazinylamides of betulinic and glycyrrhetic acids

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Doklady Bashkirskogo Universiteta. 2019. Volume 4. No. 6. pp. 608-612.

Authors

Giniyatullina G. V.*
Ufa Institute of Chemistry, Ufa Federal Research Centre of the Russian Academy of Science
71 Oktyabrya Avenue, 450054 Ufa, Republic of Bashkortostan, Russia
Avzalova I. I.
Bashkir State University
32 Zaki Validi Street, 450076 Ufa, Republic of Bashkortostan, Russia
Buranbaeva A. S.
Bashkir State University
32 Zaki Validi Street, 450076 Ufa, Republic of Bashkortostan, Russia
Zileeva Z. R.
Institute of Biochemistry and Genetics, Ufa Federal Research Centre of the Russian Academy of Sciences
71 Oktyabrya Avenue, 450054, Ufa, Republic of Bashkortostan, Russia
Ivanova T. V.
Institute of Biochemistry and Genetics, Ufa Federal Research Centre of the Russian Academy of Sciences
71 Oktyabrya Avenue, 450054, Ufa, Republic of Bashkortostan, Russia

Abstract

The synthesis of N-ethylpiperazinylamideglycyrrhetonic acid was carried out. A study of cytotoxicity has shown that N-ethyl- and N-methylpiperazinylamides of betulinic and glycyrrhetic acids have activity against cancer cells, but N-methylpiperazinylamides inhibit tumor cell viability more efficiently.

Keywords

  • triterpenoids
  • N-ethylpiperazinylamide
  • N-methylpiperazinylamide
  • cytotoxic activity
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