The effect of doxorubicin on Aryl hydrocarbon receptor target genes’ expression in human cell cultures

Return to list of articles
Doklady Bashkirskogo Universiteta. 2018. Volume 3. No. 6. pp. 615-618.

Authors

Vorontsova Yu. E.*
Koltzov Institute of Developmental Biology of Russian Academy of Sciences
26 Vavilov Street, 119334 Moscow, Russia
Cherezov R. O.
Koltzov Institute of Developmental Biology of Russian Academy of Sciences
26 Vavilov Street, 119334 Moscow, Russia
Simonova O. B.
Koltzov Institute of Developmental Biology of Russian Academy of Sciences
26 Vavilov Street, 119334 Moscow, Russia

Abstract

In this paper the effect of cytostatic drug doxorubicin, which has anti-tumor activity, on the expression level of the aryl-hydrocarbyl receptor target genes CYP1A1, CYP1A2, and CYP1B in human cell cultures of tumor and non-tumor origin was studied. It was shown that there is no noticeable effect of doxorubicin on the level of their expression.

Keywords

  • aryl-hydrocarbon receptor AHR
  • doxorubicin
  • CYP1
  • cell culture
Return to list of articles